ASTM E1163

Standard Test Method for Estimating Acute Oral Toxicity in Rats
Standard Test Method for Estimating Acute Oral Toxicity in Rats
Standard Test Method for Estimating Acute Oral Toxicity in Rats
Standard Test Method for Estimating Acute Oral Toxicity in Rats
Standard Test Method for Estimating Acute Oral Toxicity in Rats
STANDARD TEST METHOD FOR ESTIMATING ACUTE ORAL TOXICITY IN RATS

: ASTM

: 2220000257393

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Format
$46.00
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Publication Date: 11/01/2010 - Complete Document Changes Incorporated

Description :

This test method determines the lethality (LD50 value, slope and 95 % confidence interval (CI)) and signs of acute toxicity from a material using a limited number of rats. The technique used in this test method is referred to as the “Stagewise, Adaptive Dose Method.”2 This test method is an alternative to the classical LD50 test and is applicable to both liquids and solids.

This test method is not recommended for test materials which typically produce deaths beyond two days postdosing.

This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.

2 Feder, P.I., Statistical Design Considerations for Stagewise, stagewise, adaptive dose allocation in dose responsive studies. In: Peace, Karl E., ed. Biopharmaceutical sequential statistical applications. New York: Marcel Dekker 1992.

 

 

Document Type : Complete Document

Language : English

Page Count : 3

Publication Date : 11/01/2010

Revision : 10

Status : Current

Supplement : W/

Title : Standard Test Method for Estimating Acute Oral Toxicity in Rats

Publication Date: 11/01/2010 - Complete Document

Description :

This test method determines the lethality (LD50 value, slope and 95% confidence interval (CI)) and signs of acute toxicity from a material using a limited number of rats. The technique used in this test method is referred to as the "Stagewise, Adaptive Dose Method."2 This test method is an alternative to the classical LD50 test and is applicable to both liquids and solids.

This test method is not recommended for test materials which typically produce deaths beyond 2 days postdosing.

This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.

2 Feder, P.I., Statistical Design Considerations for Stagewise, stagewise, adaptive dose allocation in dose responsive studies. In: Peace, Karl E., ed. Biopharmaceutical sequential statistical applications. New York: Marcel Dekker 1992.

 

Document Type : Complete Document

Language : English

Page Count : 3

Publication Date : 11/01/2010

Revision : 10

Status : Historical

Title : Standard Test Method for Estimating Acute Oral Toxicity in Rats

Publication Date: 10/10/1998 - Complete Document Changes Incorporated

Description :

This test method determines the lethality (LD50 value) and signs of acute toxicity from a material using a limited number of rats. The technique used in this test method is referred to as the "Up-and-Down Procedure." This test method is an alternative to the classical LD50 test and is applicable to both liquids and solids.

This test method is not recommended for test materials which typically produce deaths beyond 2 days postdosing.

This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.

Document Type : Complete Document

Language : English

Page Count : 3

Publication Date : 10/10/1998

Revision : 98

Status : Historical

Supplement : W/

Title : Standard Test Method for Estimating Acute Oral Toxicity in Rats

Publication Date: 10/10/1998 - Complete Document

Description :

1. Scope

1.1 This test method determines the lethality (LD50 value) and signs of acute toxicity from a material using a limited number of rats. The technique used in this test method is referred to as the "Up-and-Down Procedure." This test method is an alternative to the classical LD50 test and is applicable to both liquids and solids.

1.2 This test method is not recommended for test materials which typically produce deaths beyond 2 days postdosing.

1.3 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.

Document Type : Complete Document

Language : English

Page Count : 3

Publication Date : 10/10/1998

Revision : 98

Status : Historical

Title : Standard Test Method for Estimating Acute Oral Toxicity in Rats

Publication Date: 01/01/1990 - Complete Document

Document Type : Complete Document

Language : English

Page Count : 6

Publication Date : 01/01/1990

Revision : 90

Status : Historical

Title : Standard Test Method for Estimating Acute Oral Toxicity in Rats

Publication Date: 04/24/1987 - Complete Document

Document Type : Complete Document

Language : English

Page Count : 5

Publication Date : 04/24/1987

Revision : 87

Status : Historical

Title : STANDARD TEST METHOD FOR ESTIMATING ACUTE ORAL TOXICITY IN RATS